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Confirmations, Reviews and Citations of the work of Correa & Axelrad

Follows a list of select references to the joint work of Dr. Paulo N. Correa and Prof. Arthur A. Axelrad.

On the discovery of the IGF-1 hypersensitivity of Polycythemia rubra vera
Experimental Follow-ups
On the effect of erythropoietin in erythropoiesis
On the effect of retinoids in erythropoiesis, and vitamin A anemia
On the effect of IGF-1 in erythropoiesis and role in anemia
On the hypersensitivity of essential thrombocytopenia to thrombopoietin
On myeloproliferative disorders
On Diamond-Blackfan Anemia
Select citation links: to Main Titles only

I. On the discovery of the IGF-1 hypersensitivity of Polycythemia rubra vera

I.1. Experimental and clinical verification of the molecular and cellular model
Staerk, J et al (2007) "JAK2, son mutant V617F, et les récepteurs de cytokines", Pathologie Biologie, Mar 2007, 55:88.

Staerk, J et al (2005) "JAK1 and Tyk2 Activation by the Homologous Polycythemia Vera JAK2 V617F Mutation: Cross-talk with IGF1 receptor", Journal of Biological Chemistry, 280:41893, ASBMB

Excerpt:  "One hallmark of Polycythemia vera is represented by hypersensitivity of erythroid progenitors to growth factors, such as the IGF1 (18, 19). Our results show that, indeed, JAK2 V617F leads to strong synergizes with IGF1R, leading to IGF1-dependent cell proliferation and further activation of JAK2, STAT5, and STAT3. This may be mediated by expression of adaptors that connect the IGF1R to the mutant JAKs or by a direct interaction between IGF1R and the mutated JAKs."

Steidl, U et al (2005) "Distinct Gene Expression Pattern of Malignant Hematopoietic Stem and Progenitor Cells in Polycythemia Vera", Hematopoietic Stem Cells, 1044:94, Annals of the New York Academy of Sciences, NYAS

Tefferi A & Gilliland DG (2005) "The JAK2 V617F tyrosine kinase mutation in myeloproliferative disorders: status report and immediate implications for disease classification and diagnosis", Mayo Clin Proc, 80:947

Van Maerken, T et al (2004) "Familial and Congenital Polycythemias: A Diagnostic Approach", Journal of Pediatric Hematology/Oncology, 26:407

Damen JE et al (1998) "The Hyperresponsiveness of Cells Expressing Truncated Erythropoietin Receptors Is Contingent on Insulin-Like Growth Factor-1 in Fetal Calf Serum", Blood, 92:425, Am Soc Hematology

Grellier, P et al (1996) "Remission of Polycythemia Vera after Surgical Cure of Acromegaly ", Annals of Internal Medicine, 124:495

I.2. Reviews
Ming C, Randall JO & Youli Z (2006) "Polycythemia Vera: New Clinicopathologic Perspectives", D Sources, Archives of Pathology and Laboratory Medicine, 130:1126, arpa.allenpress.com

Pahl HL (2003) "Molecular Markers in Myeloproliferative Disorders: From Classification to Prognosis?", Hematology, 8:199, Taylor & Francis

Spivak JL (2002) "Polycythemia vera: myths, mechanisms, and management", Blood, 100:4272, Am Soc Hematology

Zumkeller W (2002) "The Insulin-like Growth Factor System in Hematopoietic Cells", Leukemia & Lymphoma, 43:487, Taylor & Francis

Pahl HL (2000) "Towards a molecular understanding of polycythemia rubra vera", Eur. J. Biochem. 267:3395, FEBS Journal, FEBS

Emanuel PD (1999) "Myelodysplasia and myeloproliferative disorders in childhood: an update", British Journal of Haematology, 105, 852, Blackwell Synergy

Prchal JF & Prchal JT (1999) "Molecular basis for polycythemia", Current Opinion Hematology, 6:100, www.co-hematology.com

Fernandez-Luna JL et al (1998) " Pathogenesis of polycythemia vera", Haematologica, 83:150, www.haematologica.org

Prchal JT & Prchal JF (1994) "Evolving understanding of the cellular defect in polycythemia vera: implications for its clinical diagnosis and molecular pathophysiology", Blood, 83:1, Am Soc Hematology

II. On the effect of erythropoietin in erythropoiesis

Halvorsen S & Bechensteen AG (2002) "Physiology of erythropoietin during mammalian development", Acta Paediatrica, 91:17, Taylor & Francis [Review]

Issaad C & Vainchenker W (1994) "Growth of erythroid colonies in chronic myelogenous leukemia is independent of erythropoietin only in the presence of steel factor", Blood, 84:3447, Am Soc Hematology, [Experimental]

III. On the effect of retinoids in erythropoiesis, and vitamin A anemia:

Michael B Zimmermann, MB et al (2006) "Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron", American Journal of Clinical Nutrition, 84:580 [Experimental]

Hess SY, Thurnham DI, Hurrell RF (2005) "Influence of provitamin A carotenoids on iron, zinc and vitamin A status", Harvest Plus Technical Monographs, www.harvestplus.org [Review]

Semba RD & Bloem MW (2002) "The anemia of vitamin A deficiency: epidemiology and pathogenesis", European Journal of Clinical Nutrition, 56:271, www.nature.com [Review]

Perrin MC, Blanchet JP & Mouchiroud G (1997) "Modulation of human and mouse erythropoiesis by thyroid hormone and retinoic acid: evidence for specific effects at different steps of the erythroid pathway", Hematology and Cell Therapy, 39:19, Springer [Experimental confirmation]

IV. On the effect of IGF-1 in erythropoiesis and role in anemia

Donnelly, S (2003) "New insights into renal anemia", Canadian Journal of Diabetes, 27:178 [Experimental]

V. On the hypersensitivity of essential thrombocytaemia to thrombopoietin

AI Schafer (2001) "Thrombocytosis and thrombocythemia", Blood Reviews, 15:159, Elsevier [Review]

VI. On myeloproliferative disorders

Van Etten RA, Shannon KM (2004) "Focus on myeloproliferative diseases and myelodysplastic syndromes", Cancer Cell, 6:547,2004 www.tufts-mori.org [Review]

Pahl HL (2003) "Molecular Markers in Myeloproliferative Disorders: From Classification to Prognosis?", Hematology, 8:199, Taylor & Francis [Review]

Albitar M & Freireich EJ (2000) "Molecular Defects in Chronic Myeloproliferative Disorders", Molecular Medicine, muse.jhu.edu [Review]

VII. On Diamond-Blackfan Anemia

Gillio AP, Gabrilove JL (1993) "Cytokine treatment of inherited bone marrow failure syndromes", Blood, 81:1669, Am Soc Hematology [Review]

VIII. Select Citations links: to Main Titles only

Correa PN, Eskinazi D, Axelrad A (1994) " Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium", Blood, 83:99, Am Soc Hematology [Google Scholar lists 118 citations]

Correa PN, Axelrad AA (1991) "Production of erythropoietic bursts by progenitor cells from adult human peripheral blood in an improved serum-free medium: role of IGF-I", Blood, 78:2823, Am Soc Hematology [Google Scholar lists 44 citations]

Mirza AM, Correa PN, Axelrad AA (1995) "Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor I receptor beta subunit in circulating mononuclear cells of patients with polycythemia vera", Blood, 86:877, ncbi.nlm.nih.gov [Google Scholar lists 40 citations]

Axelrad AA, Eskinazi D, Correa PN, Amato D (2000) "Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia", Blood, 96:3310, Am Soc Hematology [Google Scholar lists 72 citations]
Olivieri NF, Grunberger T, Ben-David Y, Ng J, Williams DE, Lyman S, Anderson, DM, Axelrad AA, Correa PN, Bernstein A, Freedman MH (1991) "Diamond-Blackfan Anemia: Heterogenous response of hematopoietic progenitor cells in vitro to the protein product of the steel locus", Blood, 78, 9:2211. [Google Scholar lists 25 citations]
Freedman MH, Grunberger T, Correa P, Axelrad AA, Dube ID, Cohen A (1993) "Autocrine and paracrine growth control by granulocyte-monocyte colony- stimulating factor of acute lymphoblastic leukemia cells", Blood, 81:3068. [Google Scholar lists 25 citations]


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